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Talanta. 2009 Apr 30;78(2):418-23. doi: 10.1016/j.talanta.2008.11.042. Epub 2008 Dec 3.

Solid-phase molecularly imprinted pre-concentration and spectrophotometric determination of isoxicam in pharmaceuticals and human serum.

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Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.


A selective molecularly imprinted polymer (MIP) has been synthesized for isoxicam pre-concentration, followed by its spectrophotometric determination based on hydrogen bonding interactions between examined drug and alizarin yellow GG. This method is able to evaluate isoxicam in range of 1.0 x 10(-3) to 20.0 microg mL(-1), with a limit of determination of 1.0 ng mL(-1). The retention capacity and pre-concentration factor of prepared sorbent are 18.5 mg g(-1) and 200, respectively; and the prepared MIPs can be reused at least for five times. The MIP capability for isoxicam selection and extraction from the solution is higher than non-imprinted polymer (NIP). Under optimum conditions, this procedure can be successfully applied to assay trace amounts of isoxicam in pharmaceutical and biological samples.

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