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Cell. 2009 Feb 6;136(3):399-400. doi: 10.1016/j.cell.2009.01.021.

An amino acid shuffle activates mTORC1.

Author information

1
Biozentrum, University of Basel, Basel, Switzerland.

Abstract

The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.

PMID:
19203575
DOI:
10.1016/j.cell.2009.01.021
[Indexed for MEDLINE]
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