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Pediatr Endocrinol Rev. 2008 Dec;6(2):241-7.

Low birth weight and catch-up-growth associated with metabolic syndrome: a ten year systematic review.

Author information

1
Bambino Gesu' Children's Hospital and Research Institute, Dept. of Hepato-Gastroenterology and Nutrition, Rome, Italy. nobili66@yahoo.it

Abstract

OBJECTIVE:

We conducted a systematic review in order to: i. summarize the relationship between low birth weight, catch-up-growth and the metabolic syndrome, from publications during the past 10 years; and ii. study the potential role of an alternative nutritional approach to side effects of catch-up-growth.

METHODS:

We reviewed all papers published in the past ten years assessing the possible association between low birth weight, catch-up-growth and the occurrence of some components of the metabolic syndrome, including insulin resistance, type 2 diabetes, dyslipidemia and non-alcoholic fatty liver disease.

RESULTS:

We found 57 studies which described the relationship between metabolic syndrome associated features and low birth weight and catch-up-growth. The majority of the studies in children, adolescents and adults born small for gestational age (SGA) suggested that insulin resistance could represent the prelude to other metabolic disorders.

CONCLUSIONS:

Both low birth weight and catch-up-growth seem to correlate with some aspects of a later metabolic syndrome.

PMID:
19202511
[Indexed for MEDLINE]

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