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Leuk Res. 2009 Oct;33(10):1352-6. doi: 10.1016/j.leukres.2009.01.009. Epub 2009 Feb 8.

Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.

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Istituto di Ematologia, Universita' Cattolica S. Cuore, Rome, Italy.


We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.

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