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Fertil Steril. 2010 Apr;93(6):1851-8. doi: 10.1016/j.fertnstert.2008.12.062. Epub 2009 Feb 6.

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium.

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Department of Obstetrics and Gynecology, Saiseikai Shimonoseki General Hospital, Kifunecho, Shimonoseki, Japan.



To examine whether thin endometria can be improved by increasing uterine radial artery (uRA) blood flow.


A prospective observational study.


University hospital and city general hospital.


Sixty-one patients with a thin endometrium (endometrial thickness [EM] <8 mm) and high radial artery-resistance index of uRA (RA-RI >or=0.81).


Vitamin E (600 mg/day, n = 25), l-arginine (6 g/day, n = 9), or sildenafil citrate (100 mg/day, intravaginally, n = 12) was given.


EM and RA-RI were assessed by transvaginal color-pulsed Doppler ultrasound.


Vitamin E improved RA-RI in 18 (72%) out of 25 patients and EM in 13 (52%) out of 25 patients. L-arginine improved RA-RI in eight (89%) out of nine patients and EM in six (67%) patients. Sildenafil citrate improved RA-RI and EM in 11 (92%) out of 12 patients. In the control group (n = 10), who received no medication to increase uRA-blood flow, only one (10%) patient improved in RA-RI and EM. The effect of vitamin E was histologically examined in the endometrium (n = 5). Vitamin E improved the glandular epithelial growth, development of blood vessels, and vascular endothelial growth factor protein expression in the endometrium.


Vitamin E, l-arginine, or sildenafil citrate treatment improves RA-RI and EM and may be useful for the patients with a thin endometrium.

[Indexed for MEDLINE]

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