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Clin Transplant. 2009 Jan-Feb;23(1):140-5. doi: 10.1111/j.1399-0012.2008.00953.x.

Administration of donor-derived transplant acceptance-inducing cells to the recipients of renal transplants from deceased donors is technically feasible.

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Department of General and Cardiothoracic Surgery, Laboratory for Transplantation Research, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.


Patient KW, a 36-yr-old male renal transplant recipient, received transplant acceptance-inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post-transplantation, the patient's conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post-transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four-yr follow-up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.

[Indexed for MEDLINE]

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