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Clin Sci (Lond). 2009 Mar;116(6):451-65. doi: 10.1042/CS20080502.

Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential.

Author information

1
Laboratory of NF-kappaB Signaling, Institute for Molecular and Cell Biology (A*STAR), 61, Proteos, 138673 Singapore.

Abstract

The NF-kappaB (nuclear factor kappaB) family of transcription factors are involved in a myriad of activities, including the regulation of immune responses, maturation of immune cells, development of secondary lymphoid organs and osteoclastogenesis. Fine tuning by positive and negative regulators keeps the NF-kappaB signalling pathway in check. Microbial products and genetic alterations in NF-kappaB and other signalling pathway components can lead to deregulation of NF-kappaB signalling in several human diseases, including cancers and chronic inflammatory disorders. NF-kappaB-pathway-specific therapies are being actively investigated, and these hold promises as interventions of NF-kappaB-related ailments.

PMID:
19200055
DOI:
10.1042/CS20080502
[Indexed for MEDLINE]

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