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Curr Drug Targets. 2009 Feb;10(2):104-9.

Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma.

Author information

1
Scott & White Cancer Research Institute, 5701 S. Airport Road, Temple, TX 76502, USA. afrankel@swmail.sw.org

Abstract

The recombinant CD3 immunotoxin, A-dmDT(390)-bisFv(UCHT1), composed of the catalytic and translocation domains of diphtheria toxin fused to two single chain Fv fragments of an anti-CD3epsilon monoclonal antibody was administered to five patients with cutaneous T cell lymphoma (CTCL) by eight 15 min intravenous infusions over four days. Side effects were fever, chills, nausea, hypoalbuminemia, transaminasemia and reactivation of EBV and CMV. Half-life of drug was 40 min. Anti-immunotoxin antibodies developed in all patients after two weeks. Two patients had partial remissions lasting 1 and 6+ months. The agent is undergoing further dose escalation and shows promising results in this disease.

PMID:
19199905
[Indexed for MEDLINE]

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