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Nano Lett. 2009 Feb;9(2):716-20. doi: 10.1021/nl803219f.

Biomimetic nanowire coatings for next generation adhesive drug delivery systems.

Author information

1
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA. kayte@berkeley.edu

Abstract

Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.While some chemically modified, microstructured surfaces have been studied in aqueous environments,adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.

PMID:
19199759
PMCID:
PMC2824765
DOI:
10.1021/nl803219f
[Indexed for MEDLINE]
Free PMC Article
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