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J Am Chem Soc. 2009 Mar 4;131(8):2766-7. doi: 10.1021/ja807714j.

Hydrophilic fluorescent nanogel thermometer for intracellular thermometry.

Author information

1
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

The first methodology to measure intracellular temperature is described. A highly hydrophilic fluorescent nanogel thermometer developed for this purpose stays in the cytoplasm and emits stronger fluorescence at a higher temperature. Thus, intracellular temperature variations associated with biological processes can be monitored by this novel thermometer with a temperature resolution of better than 0.5 degrees C.

PMID:
19199610
DOI:
10.1021/ja807714j
[Indexed for MEDLINE]

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