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J Infect Dis. 2009 Mar 1;199(5):666-72. doi: 10.1086/596658.

Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis.

Author information

1
Faculty of Biotechnology, University of Naples Federico II, Naples, Italy.

Abstract

BACKGROUND:

Mannose-binding lectin (MBL) activates the complement system in an antibody-independent manner, enhances complement-mediated phagocytosis, and plays a major role in the regulation of inflammatory cytokine release by monocytes.

METHODS:

Case patients (277 patients with pulmonary tuberculosis) and control subjects (288 household contacts) were tested by polymerase chain reaction (PCR) for polymorphisms at the promoter and the exon 1 regions of the MBL gene. Diagnosis of pulmonary tuberculosis, based on findings from chest radiography and sputum smear examination, was confirmed by PCR and bacteriological tests.

RESULTS:

HYA/HYA subjects were protected against tuberculosis (odds ratio [OR], 0.09 [95% confidence interval {CI}], 0.023-0.408; P < 1 X 10 (-6)). LYB/LYD subjects were susceptible to disease (OR, 49 [95% CI, 2.9-812.5]; P < 1 X 10(-6)).

CONCLUSIONS:

This study supports the conclusion that MBL can protect or predispose the host to tuberculosis, depending on the host's haplotype pair.

PMID:
19199550
DOI:
10.1086/596658
[Indexed for MEDLINE]

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