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Angew Chem Int Ed Engl. 2009;48(11):2020-3. doi: 10.1002/anie.200805365.

Incorporation of tellurocysteine into glutathione transferase generates high glutathione peroxidase efficiency.

Author information

1
State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 2699 Qianjin Road, Changchun 130012, China.

Abstract

A rival to native peroxidase! An existing binding site for glutathione was combined with the catalytic residue tellurocysteine by using an auxotrophic expression system to create an engineered enzyme that functions as a glutathione peroxidase from the scaffold of a glutathione transferase (see picture). The catalytic activity of the telluroenzyme in the reduction of hydroperoxides by glutathione is comparable to that of native glutathione peroxidase.

PMID:
19199319
DOI:
10.1002/anie.200805365
[Indexed for MEDLINE]

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