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Arch Gynecol Obstet. 2009 Sep;280(3):505-7. doi: 10.1007/s00404-009-0943-1. Epub 2009 Feb 6.

Three dimensional ultrasound diagnosis of caudal regression syndrome at 14 gestational weeks.

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Division of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel.


Caudal regression syndrome (CRS) is a rare complex abnormality, characterized by agenesis of the sacrum and lumbar spine, with lower limb neurological deficit and accompanying deformities of the pelvis, lower extremities, genitourinary, gastrointestinal and cardiac systems. Pregnancies complicated by insulin treated diabetes carry higher risk of fetal CRS than non-diabetic pregnancies. Three dimensional (3D) and four dimensional (4D) ultrasound may assist in early detection of CRS. We report a case of CRS diagnosed by 3D and 4D ultrasound examination at 14 weeks of gestation in a diabetic patient.

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