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Nat Rev Microbiol. 2009 Mar;7(3):215-25. doi: 10.1038/nrmicro2087. Epub 2009 Feb 9.

DSB proteins and bacterial pathogenicity.

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The University of Queensland, Institute for Molecular Bioscience, Queensland 4072, Australia.


If DNA is the information of life, then proteins are the machines of life--but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.

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