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Nat Genet. 2009 Mar;41(3):280-2. doi: 10.1038/ng.307. Epub 2009 Feb 8.

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

Author information

1
Medizinische Klinik II, Universität zu Lübeck, 23538 Lübeck, Germany. j.erdmann@cardiogenics.eu

Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

PMID:
19198612
PMCID:
PMC2695543
DOI:
10.1038/ng.307
[Indexed for MEDLINE]
Free PMC Article

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