The effect of drinking waters with their altered structure and charge state (a total of 9 samples) on the epitheliocytes of the proventriculus, liver, and kidney was studied in rats after 6- and 12-month water consumption. It was found that in the absence of changes in the animals' morphofunctional status, the degree of water structuredness was associated with the frequency of epitheliocytes with nuclear protrusion into the proventricular mucosa following 6-month water consumption and with the manifestations of adipose degeneration, hepatocytic alterations, and stromal overgrowth into the liver after 12-month water use. The biological implication of little studied (additional) types of anomalies of the proventricular epitheliocytic nucleus: the necrotic nature of a perinuclear vacuole, the predominant implication of nuclear pyknosis and rrhexis to apoptosis and the association of binucleated patterns with the restorative proliferation of hepatic and renal tissues, was specified.