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Rinsho Shinkeigaku. 2008 Nov;48(11):981-3.

[Lewy body formation in Parkinson's disease: neurodegeneration or neuroprotection?].

[Article in Japanese]

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1
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine.

Abstract

The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. To date, more than 70 molecules have been identified in LBs, in which alpha-synuclein is a major constituent of LB fibrils. Alpha-synuclein immunohistochemistry reveals that diffuse cytoplasmic staining develops into pale bodies via compaction, and that LBs arise from the peripheral portion of pale bodies. Abnormal accumulation of alpha-synuclein (diffuse cytoplasmic staining, pale bodies and LBs) is found in 10% of pigmented neurons in the substantia nigra and more than 50% of those in the locus ceruleus in PD. Recent studies have suggested that oligomers and protofibrils of alpha-synuclein are cytotoxic, and that pale bodies and LBs may represent a cytoprotective mechanism in PD.

PMID:
19198138
[Indexed for MEDLINE]
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