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Curr Opin Investig Drugs. 2009 Feb;10(2):121-8.

Ribosomal frameshifting: an emerging drug target for HIV.

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  • 1University of Rochester, Department of Dermatology, Rochester, New York, NY 14642, USA.


Combating HIV currently remains one of the key public health challenges. While immense effort has been invested in the development of HIV-targeted therapeutic agents, interfering with protein synthesis is a relatively unexplored area. HIV has an absolute requirement for a -1 ribosomal frameshift event during translation that constitutes a potentially attractive target for interfering with the viral life cycle. Research suggests that while a considerable amount of investigation is still required, targeting frameshifting in HIV with small molecules, peptides and oligonucleotides is feasible.

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