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Nat Rev Mol Cell Biol. 2009 Jan;10(1):9-20. doi: 10.1038/nrm2609.

The 3Ms of central spindle assembly: microtubules, motors and MAPs.

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1
Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA. mglotzer@uchicago.edu

Abstract

During metaphase, sister chromatids are positioned at the midpoint of the microtubule-based mitotic spindle in preparation for their segregation. The onset of anaphase triggers inactivation of the key mitotic kinase cyclin-dependent kinase 1 (CDK1) and the polewards movement of sister chromatids. During anaphase, the mitotic spindle reorganizes in preparation for cytokinesis. Kinesin motor proteins and microtubule-associated proteins bundle the plus ends of interpolar microtubules and generate the central spindle, which regulates cleavage furrow initiation and the completion of cytokinesis. Complementary approaches, including cell biology, genetics and computational modelling, have provided new insights into the mechanism and regulation of central spindle assembly.

PMID:
19197328
PMCID:
PMC2789570
DOI:
10.1038/nrm2609
[Indexed for MEDLINE]
Free PMC Article
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