Abstract
Large-cell neuroendocrine cervical carcinoma is a rare and aggressive cancer that tends to spread and recur early despite intensive multimodal treatment. The optimal mode of therapy is still controversial and management during pregnancy is challenging because foetal well-being must also be considered. We report a patient with clinically stage IIB large-cell neuroendocrine cervical carcinoma who presented with a cervical polyp and vaginal bleeding at 18 weeks of pregnancy. The patient received concurrent chemotherapy and radiation after termination of pregnancy and remained in complete remission 21 months after completion of treatment.
MeSH terms
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Abortion, Induced
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Adult
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Antineoplastic Agents, Phytogenic / administration & dosage
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Carcinoma, Large Cell* / drug therapy
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Carcinoma, Large Cell* / pathology
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Carcinoma, Large Cell* / radiotherapy
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Carcinoma, Neuroendocrine* / drug therapy
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Carcinoma, Neuroendocrine* / pathology
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Carcinoma, Neuroendocrine* / radiotherapy
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Cervix Uteri / pathology
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Etoposide / administration & dosage
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Female
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Humans
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Polyps / pathology
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Pregnancy
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Pregnancy Complications, Neoplastic* / drug therapy
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Pregnancy Complications, Neoplastic* / pathology
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Pregnancy Complications, Neoplastic* / radiotherapy
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Treatment Outcome
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Uterine Cervical Neoplasms* / drug therapy
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Uterine Cervical Neoplasms* / pathology
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Uterine Cervical Neoplasms* / radiotherapy
Substances
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Antineoplastic Agents, Phytogenic
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Etoposide