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Methods Cell Biol. 2008;90:399-415. doi: 10.1016/S0091-679X(08)00817-0.

A system biology approach to understand functional activity of cell communication systems.

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Department of Computer Science, University of Rostock, 18051 Rostock, Germany.


Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.

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