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Acta Neurochir (Wien). 2009 Feb;151(2):173-5. doi: 10.1007/s00701-008-0180-6. Epub 2009 Feb 5.

Isolated Whipple disease of the brain resembling a tumour.

Author information

1
Department of Neurosurgery and Oncology, The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.

Abstract

INTRODUCTION:

Isolated Whipple disease of the central nervous system is a rare occurrence. Migratory arthralgias and gastrointestinal problems, including malabsorption, abdominal pain, diarrhea, and weight loss, are common presenting symptoms.

DISCUSSION:

For those patients with systemic signs and symptoms of Whipple disease, 6% to 43% will have clinically manifested CNS involvement that may include alterations in personality, ataxia, and dementia. We report our experience with a patient, who was successfully treated for Whipple disease 12 years prior to presentation and had a magnetic resonance image of the brain that revealed two solitary lesions resembling a tumor upon presentation.

PMID:
19194653
DOI:
10.1007/s00701-008-0180-6
[Indexed for MEDLINE]
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