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Leukemia. 2009 May;23(5):852-5. doi: 10.1038/leu.2008.371. Epub 2009 Feb 5.

MPLW515L mutation in acute megakaryoblastic leukaemia.

Author information

1
Institute of Pathology, Hannover Medical School, Hannover, Germany.

Abstract

The thrombopoietin receptor gene (MPL) is expressed in megakaryocytes and exhibits the gain of function point mutation W515K/L in approximately 5% of patients with primary myelofibrosis/idiopathic myelofibrosis (PMF) representing one subtype of the chronic myeloproliferative disorders (myeloproliferative neoplasm). A series of primary and secondary acute myeloid leukaemias (AML) with megakaryoblastic phenotype and myelofibrosis unrelated to PMF (n=12) was analysed for the MPL(W515K/L) mutation by pyrosequencing. In three cases (25%), MPL(W515L) was found and in two of these a combination with trisomy 21 or the Philadelphia chromosome occurred. None of the secondary AML cases evolving from pre-existing PMF showed MPL(W515K/L) (n=4). We conclude that MPL(W515L) occurs in a considerable proportion of acute megakaryoblastic leukaemias with myelofibrosis unrelated to PMF.

PMID:
19194467
DOI:
10.1038/leu.2008.371
[Indexed for MEDLINE]

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