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Urology. 2009 Apr;73(4):725-30, 730.e1. doi: 10.1016/j.urology.2008.11.006. Epub 2009 Feb 4.

Diet to reduce mild hyperoxaluria in patients with idiopathic calcium oxalate stone formation: a pilot study.

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1
Department of Clinical Sciences, University of Parma, Parma, Italy. antonio.nouvenne@alice.it

Abstract

OBJECTIVES:

To assess whether a normal-calcium, low-animal protein, low-salt diet is effective in reducing hyperoxaluria in idiopathic calcium oxalate nephrolithiasis compared with a traditional low-oxalate diet, routinely recommended by clinicians

METHODS:

We treated 56 patients with idiopathic calcium oxalate stone formation who presented with mild hyperoxaluria (>40 mg/d) while consuming a free diet with a normal-calcium, low-animal protein, low-salt diet for a 3-month period. We compared the results obtained with this diet with those of a historical control group of 20 hyperoxaluric patients treated in the traditional way with a low-oxalate diet

RESULTS:

After 3 months of therapy, the mean oxaluria level had decreased from 50.2 to 35.5 mg/d with the normal-calcium, low-animal protein, low-salt diet and from 45.9 to 40.2 mg/d with the traditional diet (adjusted difference between post-treatment mean value -7.3 mg/d, 95% confidence interval -12.3 to -2.2, P = .005)

CONCLUSIONS:

The results suggest that a normal-calcium, low-animal protein, low-salt diet can reduce oxalate excretion in hyperoxaluric patients. This should encourage the undertaking of a randomized-control study to confer more solid evidence in support of our findings.

PMID:
19193409
DOI:
10.1016/j.urology.2008.11.006
[Indexed for MEDLINE]
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