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Clin Infect Dis. 2009 Mar 1;48(5):e53-6. doi: 10.1086/597011.

Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment.

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Sexually Transmitted Infection Outpatient Clinic, Health Service Amsterdam, Amsterdam, The Netherlands.


Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens.

[Indexed for MEDLINE]

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