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Arch Pediatr Adolesc Med. 2009 Feb;163(2):164-71. doi: 10.1001/archpedi.163.2.164.

Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era.

Collaborators (154)

Bardeguez A, Dieudonne A, Bettica L, Johnson J, Pelton SI, Cooper ER, Kay L, Regan AM, Church JA, Dunaway T, Deveikis A, Batra J, Marks S, Fineanganofo I, Keller MA, Redjal N, Wettgen S, Sullivan S, Hutton N, Griffith B, Joyner M, Keifer C, Watson D, Farley J, Paul ME, Jackson CD, Minglana F, Schwarzwald H, Boyer KM, Martinez J, McAuley JB, Haak M, Brady M, Koranyi K, Hunkler J, Callaway C, Scott GB, Mitchell CD, Florez C, Gamber J, Wara DW, Petru A, Tilton N, Muscat M, Petru A, Courville T, Gold K, Eng K, Spector SA, Viani RM, Caffery M, Norris K, Donnelly M, McGann K, Mathison C, Swetnam J, Belhorn T, Eddleman J, Pitkin B, Bonagura VR, Schuval S, Kaplan B, Colter C, Abrams EJ, Frere M, Calo D, Borkowsky W, Deygoo N, Minter M, Akleh S, Dobbins D, Wimbley D, D'Angelo L, Spiegel H, Melvin AJ, Mohan KM, Acker M, Phelps S, Rich KC, Hayani K, Camacho J, Andiman WA, Hurst L, de Jesus J, Schroeder D, Ferraro D, Perillo J, Kelly M, Rana S, Finke H, Yu P, Roa J, Kovacs A, Homans J, Neely M, Spencer L, Rathore MH, Mirza A, Thoma K, Mendoza A, Puga AM, Talero G, Blood J, Juliano S, Weinberg GA, Murante B, Laverty S, Gigliotti F, Lavoie SR, Smith TY, Gaur A, Knapp K, Patel N, Donohoe M, Febo IL, Lugo L, Santos R, Heyer I, Douglas SD, Rutstein RM, Vincent CA, Coburn PC, Foster J, Chen J, Conway D, Laguerre R, Stuard E, Nubel C, Hagmann S, Purswani M, Bamji M, Pathak I, Manwani S, Patel E, Luzuriaga K, Moriarty R, Stechenberg BW, Fisher DJ, Johnston AM, Toye M, Salazar JC, Fullerton K, Karas G, Foshee S, Mani CS, Murray DL, White C, Mancao MY, Estrada B, Wilcox RD, Silio M, Alchediak T, Borne C, Bradford S.

Author information

Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794-8111, USA.

Erratum in

  • Arch Pediatr Adolesc Med. 2009 Apr;163(4):364.



To estimate highly active antiretroviral therapy (HAART)-era incident rates for the first episode of noninfectious conditions in human immunodeficiency virus (HIV)-infected youth in order to identify HAART-era changes in the natural history of perinatal HIV infection.


Multicenter prospective cohort study.


More than 80 sites in the United States including Puerto Rico.


Perinatally HIV-infected youth.


Incidence rates (IRs) per 100 person-years were calculated for targeted noninfectious conditions occurring in perinatally HIV-infected children. A chi(2) test for linear trend was used to evaluate changes in the rates from 2001 to 2006.


Two thousand five hundred seventy-five perinatally HIV-infected children (51%, female; 59%, black, non-Hispanic) were enrolled in Pediatric AIDS Clinical Trials Group (PACTG) 219C between 2000 and 2006 and were followed up for a median of 59 months. The 10 most common noninfectious conditions were pregnancy conditions (IR = 6.16; 95% confidence interval (CI), 3.9-9.3), birth defects (IR = 0.19; 95% CI, 0.1-0.3), gynecological dysplasias (IR = 5.92; 95% CI, 3.9-8.6), condyloma (IR = 0.15; 95% CI, 0.1-0.2), encephalopathy (IR = 0.38; 95% CI, 0.3-0.5), pancreatitis (IR = 0.30; 95% CI, 0.2-0.4), cardiac disorders (IR = 0.28; 95% CI, 0.2-0.4), renal disorders (IR = 0.26; 95% CI, 0.2-0.4), peripheral neuropathy (IR = 0.23; 95% CI, 0.2-0.4), and idiopathic thrombocytic purpura (IR = 0.15; 95% CI, 0.1-0.3). Among these conditions, 5 showed significant trends, with IRs increasing over time in pregnancy-related conditions (P < .001) and gynecological dysplasias (P = .02) while IRs decreased over time for encephalopathy (P < .001), pancreatitis (P = .002), and cardiac disorders (P = .007).


Between 2001 and 2006, the incidence for 3 conditions decreased and increased for 2 others, demonstrating the change in medical issues and conditions in perinatally infected youth. Continued surveillance with appropriate tools will be needed to assess the long-term effects of HAART and HIV as well as development of new noninfectious conditions of HIV.

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