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World J Emerg Surg. 2009 Feb 2;4:7. doi: 10.1186/1749-7922-4-7.

Molecular mechanisms of traumatic brain injury: the missing link in management.

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Department of Anaesthesia and Intensive Care, Cambridge University Hospitals NHS Trust Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.


Head injury is common, sometimes requires intensive care unit admission, and is associated with significant mortality and morbidity. A gap still remains in the understanding of the molecular mechanism of this condition. This review is aimed at providing a general overview of the molecular mechanisms involved in traumatic brain injury to a busy clinician. It will encompass the pathophysiology in traumatic brain injury including apoptosis, the role of molecules and genes, and a brief mention of possible pharmacological therapies.

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