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Curr Opin Microbiol. 2009 Feb;12(1):88-93. doi: 10.1016/j.mib.2009.01.001. Epub 2009 Jan 29.

Virulence factor secretion and translocation by Bordetella species.

Author information

1
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Here we review the Bordetella virulence secretome with an emphasis on factors that translocate into target cells. Recent advances in understanding the functions of adenylate cyclase toxin, a type 1 secretion system (T1SS) substrate, and pertussis toxin, a type IV secretion system (T4SS) substrate, are briefly described and a compilation of additional secretion systems and secreted factors is provided. Particular attention is devoted to the Bsc type III secretion system (T3SS) and controversies surrounding it. Efforts to identify effector proteins, characterize in vitro and in vivo phenotypes, and the potential role of type III secretion during human infections are discussed.

PMID:
19186097
PMCID:
PMC2703423
DOI:
10.1016/j.mib.2009.01.001
[Indexed for MEDLINE]
Free PMC Article

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