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Curr Opin Cell Biol. 2009 Feb;21(1):20-7. doi: 10.1016/j.ceb.2009.01.006. Epub 2009 Jan 29.

Actin and endocytosis: mechanisms and phylogeny.

Author information

1
Department of Cell Biology, Washington University Medical School, St Louis, MO, USA.

Abstract

The regulated assembly of actin filament networks is a crucial part of endocytosis, with crucial temporal and spatial relationships between proteins of the endocytic and actin assembly machinery. Of particular importance has been a wealth of studies in budding and fission yeast. Cell biology approaches, combined with molecular genetics, have begun to uncover the complexity of the regulation of actin dynamics during the endocytic process. In a wide range of organisms, clathrin-mediated endocytosis appears to be linked to Arp2/3-mediated actin assembly. The conservation of the components, across a wide range eukaryotic species, suggests that the partnership between endocytosis and actin may be evolutionarily ancient.

PMID:
19186047
PMCID:
PMC2670849
DOI:
10.1016/j.ceb.2009.01.006
[Indexed for MEDLINE]
Free PMC Article

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