Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Pharmacol. 2009 Feb;9(1):39-45. doi: 10.1016/j.coph.2008.12.018.

The brain hypocretins and their receptors: mediators of allostatic arousal.

Author information

1
Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, CA 94304, United States.

Abstract

The hypocretins (abbreviated 'Hcrts' - also called 'orexins') are two neuropeptides secreted exclusively by a small population of neurons in the lateral hypothalamus. These peptides bind to two receptors located throughout the brain in nuclei associated with diverse cognitive and physiological functions. Initially, the brain Hcrt system was found to have a major role in the regulation of sleep/wake transitions. More recent studies indicate Hcrts may play a role in other physiological functions, including food intake, addiction, and stress. Taken together, these studies suggest a general role for Hcrts in mediating arousal, especially when an organism must respond to unexpected stressors and challenges in the environment.

PMID:
19185540
PMCID:
PMC3791851
DOI:
10.1016/j.coph.2008.12.018
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center