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Chembiochem. 2009 Mar 2;10(4):645-9. doi: 10.1002/cbic.200800769.

A peptide antagonist of the TLR4-MD2 interaction.

Author information

1
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA.

Abstract

Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling.

PMID:
19184989
PMCID:
PMC2982775
DOI:
10.1002/cbic.200800769
[Indexed for MEDLINE]
Free PMC Article

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