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Aliment Pharmacol Ther. 2009 Mar 15;29(6):669-76. doi: 10.1111/j.1365-2036.2008.03923.x. Epub 2008 Dec 19.

Patient acceptance and clinical impact of Bravo monitoring in patients with previous failed catheter-based studies.

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1
Functional GI Disease Unit, Clinic for Gastroenterology and Hepatology, University Hospital of Zürich, Zürich, Switzerland.

Abstract

BACKGROUND:

Standard pH monitoring is performed over 24 h with a naso-oesophageal catheter (C-pH). Limitations include naso-pharyngeal discomfort, nausea and social embarrassment resulting in reduced reflux-provoking activities. Recently a catheter-free pH-monitoring technique has become available. The tolerability and diagnostic yield of this system in patients who failed standard monitoring remain unknown.

AIM:

To examine the tolerability and diagnostic outcome of catheter-free pH-monitoring technique in patients who failed standard monitoring.

METHODS:

Patients referred for C-pH and catheter-free pH monitoring completed a tolerability questionnaire. Acid exposure in the distal oesophagus and symptom index (SI) were reviewed.

RESULTS:

Over 4 years, 883/1751 (50%) of patients with typical reflux symptoms referred for C-pH were diagnosed with gastro-oesophageal reflux disease (GERD) based on a pathological percentage time acid exposure (%time pH <4);134 (8%) patients failed C-pH and, of these, 129 successfully completed 2-day catheter-free pH monitoring. Ninety-eight (76%) of these patients had a pathological percentage pH <4 on either day compared with 49/102 (49%) of contemporaneous C-pH patients (P < 0.01). There was no difference in SI for heartburn (35% vs. 42%; P = 0.49). The questionnaire demonstrated a preference for catheter-free pH monitoring (96%) with less restriction in activities of daily living, naso-pharyngeal discomfort, dysphagia and chest pain.

CONCLUSIONS:

Tolerance and satisfaction with catheter-free pH monitoring are high in patients who had previously failed C-pH; catheter-free pH monitoring assists the definitive diagnosis of GERD in this group.

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