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Nat Genet. 2009 Mar;41(3):277-9. doi: 10.1038/ng.299. Epub 2009 Feb 1.

Variant in the sequence of the LINGO1 gene confers risk of essential tremor.

Author information

1
deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.

Erratum in

  • Nat Genet. 2009 Apr;41(4):504.

Abstract

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected].

PMID:
19182806
PMCID:
PMC3740956
DOI:
10.1038/ng.299
[Indexed for MEDLINE]
Free PMC Article

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