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Nat Neurosci. 2009 Mar;12(3):253-5. doi: 10.1038/nn.2263. Epub 2009 Feb 1.

The precision of remote context memories does not require the hippocampus.

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1
Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.

Abstract

Although the clarity of many memories fades with time, some memories may maintain their original precision. Here we used a context discrimination procedure to evaluate whether the hippocampus is important in maintaining precision as memories mature. Spared discrimination in hippocampal-lesioned mice indicated that precise, remote context memories may be supported by extra-hippocampal brain regions.

PMID:
19182794
DOI:
10.1038/nn.2263
[Indexed for MEDLINE]
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