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Fly (Austin). 2009 Jan-Mar;3(1):78-90. Epub 2009 Jan 8.

Genetic control of programmed cell death (apoptosis) in Drosophila.

Author information

1
The University of Texas MD Anderson Cancer Center, The Genes and Development Graduate Program, Department of Biochemistry and Molecular Biology, Houston, Texas 77030, USA.

Abstract

Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.

PMID:
19182545
PMCID:
PMC2702463
[Indexed for MEDLINE]
Free PMC Article

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