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Hosp Pract (Off Ed). 1991 Oct 15;26(10):121-6.

Localization of the early-onset breast cancer gene.

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  • 1Department of Biomedical and Environmental Health Sciences, University of California School of Public Health, Berkeley.


In several susceptible families, it is clear that breast cancer is associated with a gene on band q21 of chromosome 17. On the basis of analogy, it seems probable that the rare germ-line gene is prototypical of a mutant form of a gene involved in the pathogenesis of the most common cancer in women. A major effort is now under way to sequence and clone this intriguing gene.

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