Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Chan Mug Ahn; Byong-Gon Park; Ho Bum Woo; Jungyeob Ham; Woon-Seob Shin; Seokjoon Lee

doi:10.1016/j.bmcl.2009.01.019

Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1481-3. doi: 10.1016/j.bmcl.2009.01.019. Epub 2009 Jan 11.

Authors

Chan Mug Ahn¹, Byong-Gon Park, Ho Bum Woo, Jungyeob Ham, Woon-Seob Shin, Seokjoon Lee

Affiliation

¹ Department of Basic Sciences and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea.

PMID: 19179077
DOI: 10.1016/j.bmcl.2009.01.019

Abstract

In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basilar Artery / drug effects
Basilar Artery / physiology*
Curcumin / chemical synthesis*
Curcumin / pharmacology
Dose-Response Relationship, Drug
In Vitro Techniques
Male
Molecular Mimicry* / physiology
Rabbits
Sulfinic Acids / chemical synthesis*
Sulfinic Acids / pharmacology
Vasodilation / drug effects
Vasodilation / physiology*
Vasodilator Agents / chemical synthesis
Vasodilator Agents / pharmacology

Substances

Sulfinic Acids
Vasodilator Agents
Curcumin