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Bioorg Med Chem Lett. 2009 Mar 1;19(5):1496-8. doi: 10.1016/j.bmcl.2009.01.007. Epub 2009 Jan 10.

Synthesis of citrate-ciprofloxacin conjugates.

Author information

1
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.

Abstract

Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.

PMID:
19179071
DOI:
10.1016/j.bmcl.2009.01.007
[Indexed for MEDLINE]

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