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PLoS One. 2009;4(1):e3590. doi: 10.1371/journal.pone.0003590. Epub 2009 Jan 29.

Novel biochemical markers of psychosocial stress in women.

Author information

1
Department of Clinical Sciences, Karolinska Institute, Stockholm, Sweden.

Abstract

BACKGROUND:

Prolonged psychosocial stress is a condition assessed through self-reports. Here we aimed to identify biochemical markers for screening and early intervention in women.

METHODS:

Plasma concentrations of interleukin (IL) 1-alpha, IL1-beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (INF-gamma), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), prolactin, and testosterone were measured in: 195 women on long-term sick-leave for a stress-related affective disorder, 45 women at risk for professional burnout, and 84 healthy women.

RESULTS:

We found significantly increased levels of MCP-1, VEGF and EGF in women exposed to prolonged psychosocial stress. Statistical analysis indicates that they independently associate with a significant risk for being classified as ill.

CONCLUSIONS:

MCP-1, EGF, and VEGF are potential markers for screening and early intervention in women under prolonged psychosocial stress.

PMID:
19177163
PMCID:
PMC2627901
DOI:
10.1371/journal.pone.0003590
[Indexed for MEDLINE]
Free PMC Article

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