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Cell Cycle. 2009 Feb 1;8(3):357-61. Epub 2009 Feb 21.

Mitotic crisis: the unmasking of a novel role for RPA.

Author information

1
Department of Biochemistry and New York University Cancer Institute, New York University School of Medicine, New York, New York, USA.

Abstract

Mitotic DNA damage is a constant threat to genomic integrity, yet understanding of the cellular responses to this stress remain incomplete. Recent work by Anantha et al. (2008; PNAS 105:12903-8) has found surprising evidence that RPA, the primary eukaryotic single-stranded DNA-binding protein, can stimulate the ability of cells to exit mitosis into a 2N G(1) phase. Along with providing additional discussion of this study, we review evidence suggesting that DNA replication and repair factors can modulate mitotic transit by acting through Polo-like kinase-1 (Plk1) and the centrosome. 'A crisis unmasks everyone.'-Mason Cooley, U.S. aphorist.

PMID:
19176996
PMCID:
PMC3397920
DOI:
10.4161/cc.8.3.7496
[Indexed for MEDLINE]
Free PMC Article

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