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Clin Exp Dermatol. 2009 Apr;34(3):380-4. doi: 10.1111/j.1365-2230.2008.02922.x. Epub 2008 Oct 29.

Nicotinamide and its metabolite N-methylnicotinamide increase skin vascular permeability in rats.

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1
Department of Pharmacodynamics, Medical University, Bialystok, Poland.

Abstract

BACKGROUND:

It has been suggested that topically applied nicotinamide and its metabolite N-methylnicotinamide (NMN(+)) might be useful agents for treatment of dermatological disorders such as acne vulgaris and rosacea.

AIM:

This study aimed to find out if the mechanism of these therapeutic effects depends on their vascular effects, by investigating if nicotinamide and NMN(+) are able to influence vascular permeability of the vessels in the skin on the back of Wistar rats.

METHODS AND RESULTS:

A dose-dependent increase in vascular permeability was seen in rats treated intradermally with nicotinamide and NMN(+). Interestingly, a significantly stronger effect of NMN(+) compared with nicotinamide was evident. Increased vascular permeability in rats treated with 0.5% NMN(+) ointment was seen. Moreover, indomethacin, a cyclo-oxygenase 1 and 2 inhibitor and N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, reduced the observed effects of nicotinamide and NMN(+).

CONCLUSIONS:

This study provides direct in vivo evidence that nicotinamide and its metabolite NMN(+) increase skin vascular permeability in rats by a mechanism that may involve NO and prostaglandins.

[Indexed for MEDLINE]

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