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J Cell Mol Med. 2009 Jan;13(1):24-38. doi: 10.1111/j.1582-4934.2008.00534.x.

Advances in microRNAs: implications for immunity and inflammatory diseases.

Author information

1
Department of Medicine, Unit of Dermatology and Venerology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. eniko.sonkoly@ki.se

Abstract

Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.

PMID:
19175698
PMCID:
PMC3823034
DOI:
10.1111/j.1582-4934.2008.00534.x
[Indexed for MEDLINE]
Free PMC Article

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