Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2009 Feb 18;583(4):777-81. doi: 10.1016/j.febslet.2009.01.022. Epub 2009 Jan 25.

Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response.

Author information

1
Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Abstract

In injured livers where hepatocyte growth is severely limited, facultative hepatic stem/progenitor cells, termed oval cells in rodents, are known to emerge and contribute to the regeneration process. Here, we investigated a possible involvement of Wnt signaling during mouse oval cell response and found significant upregulation of several Wnt genes including Wnt7a, Wnt7b, and Wnt10a. Accordingly, increase of beta-catenin protein was observed in oval cell compartments. Pharmacological activation of the canonical Wnt/beta-catenin signaling induced proliferation of cultured hepatic stem/progenitor cell lines. These results together implicate the role of Wnt/beta-catenin signaling in adult hepatic stem/progenitor cell response.

PMID:
19174158
DOI:
10.1016/j.febslet.2009.01.022
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center