Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Biol Sci. 2009;5(2):147-52. Epub 2009 Jan 21.

SIRT1, is it a tumor promoter or tumor suppressor?

Author information

1
Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA. chuxiad@bdg10.niddk.nih.gov

Abstract

SIRT1 has been considered as a tumor promoter because of its increased expression in some types of cancers and its role in inactivating proteins that are involved in tumor suppression and DNA damage repair. However, recent studies demonstrated that SIRT1 levels are reduced in some other types of cancers, and that SIRT1 deficiency results in genetic instability and tumorigenesis, while overexpression of SIRT1 attenuates cancer formation in mice heterozygous for tumor suppressor p53 or APC. Here, I review these recent findings and discuss the possibility that activation of SIRT1 both extends lifespan and inhibits cancer formation.

KEYWORDS:

DNA damage repair; SIRT1; tumor promoter; tumor suppressor

PMID:
19173036
PMCID:
PMC2631220
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Ivyspring International Publisher Icon for PubMed Central
    Loading ...
    Support Center