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Nat Rev Drug Discov. 2008 Sep;7(9):738-45. doi: 10.1038/nrd2606.

Perspectives on NMR in drug discovery: a technique comes of age.

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1
Burnham Institute for Medical Research, La Jolla, California 92037, USA. mpellecchia@burnham.org

Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

PMID:
19172689
PMCID:
PMC2891904
DOI:
10.1038/nrd2606
[Indexed for MEDLINE]
Free PMC Article
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