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Parasitol Res. 2009 Jun;104(6):1459-64. doi: 10.1007/s00436-009-1348-6. Epub 2009 Jan 27.

In vivo anti-malarial effect of the beta-amino alcohol 1t on Plasmodium berghei.

Author information

1
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.

Abstract

Glycerol derivatives are a class of compounds, which are easy and inexpensive to produce with potent anti-malarial activities against blood stages of Plasmodium falciparum in vitro. In the present study, one of these compounds, termed 1t, which had the lowest IC(50) values, was assessed in a murine malarial model. Nuclear magnetic resonance imaging and Balb/c mice infected with Plasmodium berghei ANKA strain were treated in a 4-day suppressive test. Mice received a once-daily intraperitoneal administration of 50 mg/Kg of the drug for 4 days. Although no parasitaemia clearance was reached, a slower parasite proliferation and a slightly longer survival time compared with the placebo group were observed.

PMID:
19172294
DOI:
10.1007/s00436-009-1348-6
[Indexed for MEDLINE]

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