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Immunol Lett. 1991 Jul;29(1-2):51-4.

Mechanisms of T lymphocyte activation.

Author information

1
School of Biological Sciences, University of Sussex, Brighton, U.K.

Abstract

The proliferation of T lymphocytes in response to an antigenic stimulus requires the successive ligation of a range of T lymphocyte receptors by MHC-presented antigen, molecules expressed on the surfaces of accessory cells and lymphokines. A range of intracellular signalling systems are involved, with the possibility of alternative activation pathways utilising different intracellular signalling systems, though protein kinase C activation appears to play a key role. Appreciation of the complexity of the response may allow more selective clinical modulation of T lymphocyte-dependent immunological responses.

PMID:
1916924
DOI:
10.1016/0165-2478(91)90198-j
[Indexed for MEDLINE]

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