Format

Send to

Choose Destination
See comment in PubMed Commons below
Infect Immun. 2009 Apr;77(4):1383-8. doi: 10.1128/IAI.01156-08. Epub 2009 Jan 21.

Direct regulation by the Vibrio cholerae regulator ToxT to modulate colonization and anticolonization pilus expression.

Author information

1
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

The pathogen Vibrio cholerae uses a large number of coordinated transcriptional regulatory events to transition from its environmental reservoir to the host and establish itself at its preferred colonization site at the host intestinal mucosa. The key regulator in this process is the AraC/XylS family transcription factor, ToxT, which plays critical roles in pathogenesis, including the regulation of two type IV pili, the anticolonization factor mannose-sensitive hemagglutinin and the toxin-coregulated pilus. Previously, it was thought ToxT required dimerization in order to effect transcriptional regulation at its cognate promoters. Here, we present evidence that ToxT directly represses transcription of the msh operon by binding to three promoters within this operon and that dimerization may not be required for transcriptional repression of target promoters by ToxT, suggesting that this regulator uses different mechanisms to modulate the transcriptional repertoire of V. cholerae.

PMID:
19168737
PMCID:
PMC2663140
DOI:
10.1128/IAI.01156-08
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center