Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2009 Mar;25(3):107-10. doi: 10.1016/j.tig.2008.12.004. Epub 2009 Jan 23.

Estimating the size of the bacterial pan-genome.

Author information

  • 1University of Connecticut Biotechnology Center, 91 North Eagleville Road, Storrs, CT 06269-3149, USA. pascal.lapierre@uconn.edu

Abstract

The 'pan-genome' denotes the set of all genes present in the genomes of a group of organisms. Here, we extend the pan-genome concept to higher taxonomic units. Using 573 sequenced genomes, we estimate the size of the bacterial pan-genome based on the frequency of occurrences of genes among sampled genomes. Using gene- and genome-centered approaches, we characterize three distinct pools of gene families that comprise the bacterial pan-genome, each evolving under different evolutionary constraints. Our findings indicate that the pan-genome of the bacterial domain is of infinite size (the Bacteria as a whole have an open pan-genome) and that approximately 250 genes per genome belong to the extended bacterial core genome.

PMID:
19168257
DOI:
10.1016/j.tig.2008.12.004
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center