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Clin Chim Acta. 2009 Apr;402(1-2):199-202. doi: 10.1016/j.cca.2008.12.034. Epub 2009 Jan 9.

The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction.

Author information

1
Russian Acad. Medical Science-Siberian branch, Novosibirsk, Russian Federation.

Abstract

BACKGROUND:

Macrophage migration inhibitory factor (MIF) is a cytokine implicated in early and advanced atherosclerosis. The aim of this study was to investigate whether polymorphism of MIF gene is associated with myocardial infarction (MI).

METHODS:

Single nucleotide polymorphism (SNP) in MIF gene (-173G/C, rs755622) was investigated in Czech (n=219) and Russian (n=240) MI patients and population control from the same geographical areas (Czech, n=137; Russian, n=174). Further, another SNP (rs1007888) located within the 3' flanking region of the MIF gene was investigated in Czech MI patients and control subjects.

RESULTS:

There were no significant differences in the distribution of MIF -173G/C genotypes, alleles or carriage rates between case and control groups in either populations. However, the GG genotype of the MIF SNP rs1007888 was associated with MI in Czech female patients (p=0.027).

CONCLUSIONS:

Taken together with previous reports, our study suggests that particular MIF gene polymorphisms may contribute to MI susceptibility in females.

PMID:
19167373
DOI:
10.1016/j.cca.2008.12.034
[Indexed for MEDLINE]

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